Monday, January 26, 2009

ADD drugs cause hallucinations,2933,482829,00.html

Drugs for attention deficit hyperactivity disorder can cause children to have hallucinations even when taken as directed, U.S. government researchers said on Monday.

U.S. Food and Drug Administration researchers analyzed data from 49 clinical studies conducted by makers of the drugs and found they can cause psychosis and mania in some patients, including some with no obvious risk factors. In some cases, children hallucinated that worms, bugs or snakes were crawling on them.

"Patients and physicians should be aware of the possibility that psychiatric symptoms consistent with psychosis or mania" might arise in the course of treatment, Dr. Andrew Mosholder and colleagues wrote in the journal Pediatrics.

Their analysis provides fresh detail about known risks of the drugs, which include Novartis AG's Ritalin and Focalin XR, Shire Plc's Adderall XR and Daytrana patch, Johnson & Johnson's Concerta, Eli Lilly and Co's Strattera and Celltech Pharmaceuticals Inc's Metadate CD.

It also includes data on Cephalon Inc's modafinil, sold as Provigil, a narcolepsy drug that was rejected as an ADHD treatment in children.

FDA spokeswoman Sandy Walsh said the data formed the basis for recent warnings about psychiatric side effects that have been added to product labels in recent years.

Millions of children use drugs to treat symptoms of ADHD, which affects about three to seven percent of U.S. children.

ADHD is marked by restlessness, impulsiveness, inattention and distractibility that can interfere with a child's ability to pay attention in school and maintain social relationships.

"The numbers of cases of psychosis or mania in pediatric clinical trials were small," Mosholder and colleagues wrote. "However, we noted a complete absence of such events with placebo treatments."

In one account, they described a 7-year-old girl who took an 18 mg dose of Strattera or atomoxetine who started talking nonstop within hours of taking her first dose.

"Two hours after taking her second dose of atomoxetine, the patient started running very fast, stopped suddenly, and fell to the ground. The patient said she had 'run into a wall' (there was no wall there)," they wrote.

"These adverse side effects are rare," said Dr. Harold Koplewicz of New York University Child Study Center, who was not involved in the study, adding that they are reversible,

"Once you stop the medicine, the side effects go away," he said in a telephone interview.

He said children under age 10 are susceptible to negative drug side effects in the same way that older adults are.

"We know that medications that affect neurochemicals in your brain to increase your attention and make you less impulsive also can have an effect on other neurochemicals in your brain that affect mood," he said.

Both Koplewicz and FDA researchers urged doctors to discuss the potential side effects with parents and children to help ease their anxiety if such symptoms should occur.


Marni said...

I have firsthand knowledge with this. My now 10 year old son's 1st grade teacher got us on the ADHD road. He was on Adderall for about 2 months, which quickly ended when he started seeing bugs in his Legos. I can't tell you how scary it is to have him pulling me down the hallway telling me there's a big brown bug in his Legos, and the only thing that settled him down was me pretending to catch it and flush it down the toilet (not letting him see of course).

Add paranoia to that list as well. He was very paranoid on Adderall.

We homeschool now and he is off EVERYTHING they ever tried him on (that never really worked anyway). Just found your blog and am interested in learning more about this, but some kids just aren't sit in the desk, face forward learners.

Karies place said...

Just as I've always thought, those drugs are dangerous and should ONLY be used in extreme cases.